Static ocular counterroll reflex in skew deviation
Identifieur interne : 000540 ( Main/Exploration ); précédent : 000539; suivant : 000541Static ocular counterroll reflex in skew deviation
Auteurs : M. Chandrakumar [Canada] ; A. Blakeman [Canada] ; H. C. Goltz [Canada] ; J. A. Sharpe [Canada] ; A. M. F. Wong [Canada]Source :
- Neurology [ 0028-3878 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Objective: The static ocular counterroll (OCR) reflex generates partially compensatory torsional eye movements during head roll. It is mediated by the utricle in the inner ear. Skew deviation is a vertical strabismus thought to be caused by imbalance in the utriculo-ocular pathway. We hypothesized that if skew deviation is indeed caused by damage to this reflex pathway, patients with skew deviation would show abnormal OCR. Methods: Eighteen patients with skew deviation caused by brainstem or cerebellar lesions and 18 normal participants viewed a target at 1 m. Ocular responses to static passive head roll-tilts of approximately 20° were recorded using search coils. Static OCR gain was calculated as the change in torsional eye position divided by the change in head position during sustained head roll. Perception of the subjective visual vertical (SVV) was also measured. Results: Group mean OCR gain was reduced by 45% in patients. At an individual level, OCR gains were asymmetric between eyes and between torsional directions in 90% of patients. In addition, the hypotropic eye incyclotorting gain was lower than the hypertropic eye excyclotorting gain during head roll toward the hypotropic eye in 94% of patients. No consistent pattern of gain asymmetry was found during head roll toward the hypertropic eye. The SVV was tilted toward the hypotropic eye. Conclusion: Static OCR gain is significantly reduced in skew deviation. Interocular and directional gain asymmetries are also prevalent. The asymmetries provide further evidence that disruption of the utriculo-ocular pathway is a mechanism for skew deviation.
Affiliations:
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Goltz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, University Health Network-Toronto Western Research Institute</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Sharpe, J A" sort="Sharpe, J A" uniqKey="Sharpe J" first="J. A." last="Sharpe">J. A. 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M. F." last="Wong">A. M. F. 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Chandrakumar</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, University Health Network-Toronto Western Research Institute</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Blakeman, A" sort="Blakeman, A" uniqKey="Blakeman A" first="A." last="Blakeman">A. Blakeman</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Goltz, H C" sort="Goltz, H C" uniqKey="Goltz H" first="H. C." last="Goltz">H. C. Goltz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, University Health Network-Toronto Western Research Institute</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Sharpe, J A" sort="Sharpe, J A" uniqKey="Sharpe J" first="J. A." last="Sharpe">J. A. Sharpe</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Ophthalmology and Vision Sciences, University Health Network-Toronto Western Research Institute</s1><s2>Toronto</s2><s3>CAN</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Neurology, University Health Network-Toronto Western Research Institute</s1><s2>Toronto</s2><s3>CAN</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Wong, A M F" sort="Wong, A M F" uniqKey="Wong A" first="A. M. F." last="Wong">A. M. F. Wong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, University Health Network-Toronto Western Research Institute</s1><s2>Toronto</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Ophthalmology and Vision Sciences, University Health Network-Toronto Western Research Institute</s1><s2>Toronto</s2><s3>CAN</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Division of Neurology, University Health Network-Toronto Western Research Institute</s1><s2>Toronto</s2><s3>CAN</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deviation</term><term>Eye</term><term>Nervous system diseases</term><term>Reflex</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term><term>Oeil</term><term>Réflexe</term><term>Déviation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: The static ocular counterroll (OCR) reflex generates partially compensatory torsional eye movements during head roll. It is mediated by the utricle in the inner ear. Skew deviation is a vertical strabismus thought to be caused by imbalance in the utriculo-ocular pathway. We hypothesized that if skew deviation is indeed caused by damage to this reflex pathway, patients with skew deviation would show abnormal OCR. Methods: Eighteen patients with skew deviation caused by brainstem or cerebellar lesions and 18 normal participants viewed a target at 1 m. Ocular responses to static passive head roll-tilts of approximately 20° were recorded using search coils. Static OCR gain was calculated as the change in torsional eye position divided by the change in head position during sustained head roll. Perception of the subjective visual vertical (SVV) was also measured. Results: Group mean OCR gain was reduced by 45% in patients. At an individual level, OCR gains were asymmetric between eyes and between torsional directions in 90% of patients. In addition, the hypotropic eye incyclotorting gain was lower than the hypertropic eye excyclotorting gain during head roll toward the hypotropic eye in 94% of patients. No consistent pattern of gain asymmetry was found during head roll toward the hypertropic eye. The SVV was tilted toward the hypotropic eye. Conclusion: Static OCR gain is significantly reduced in skew deviation. Interocular and directional gain asymmetries are also prevalent. The asymmetries provide further evidence that disruption of the utriculo-ocular pathway is a mechanism for skew deviation.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Chandrakumar, M" sort="Chandrakumar, M" uniqKey="Chandrakumar M" first="M." last="Chandrakumar">M. Chandrakumar</name></noRegion><name sortKey="Blakeman, A" sort="Blakeman, A" uniqKey="Blakeman A" first="A." last="Blakeman">A. Blakeman</name><name sortKey="Goltz, H C" sort="Goltz, H C" uniqKey="Goltz H" first="H. C." last="Goltz">H. C. Goltz</name><name sortKey="Goltz, H C" sort="Goltz, H C" uniqKey="Goltz H" first="H. C." last="Goltz">H. C. Goltz</name><name sortKey="Sharpe, J A" sort="Sharpe, J A" uniqKey="Sharpe J" first="J. A." last="Sharpe">J. A. Sharpe</name><name sortKey="Sharpe, J A" sort="Sharpe, J A" uniqKey="Sharpe J" first="J. A." last="Sharpe">J. A. Sharpe</name><name sortKey="Sharpe, J A" sort="Sharpe, J A" uniqKey="Sharpe J" first="J. A." last="Sharpe">J. A. Sharpe</name><name sortKey="Wong, A M F" sort="Wong, A M F" uniqKey="Wong A" first="A. M. F." last="Wong">A. M. F. Wong</name><name sortKey="Wong, A M F" sort="Wong, A M F" uniqKey="Wong A" first="A. M. F." last="Wong">A. M. F. Wong</name><name sortKey="Wong, A M F" sort="Wong, A M F" uniqKey="Wong A" first="A. M. F." last="Wong">A. M. F. Wong</name><name sortKey="Wong, A M F" sort="Wong, A M F" uniqKey="Wong A" first="A. M. F." last="Wong">A. M. F. Wong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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